Steve Mount
Contact Info
Phone: 301.405.6934
Office Address: 0122 Bioscience Research Bldg
Steve Mount
Affiliate Associate Professor
Associate Professor, Department of Cell Biology and Molecular Genetics

Teaching

  • BSCI 410: Molecular Genetics
  • BSCI 416, Human Genetics
  • CBMG 688I: Advanced Genetics (MOCB graduate core course)
  • CBMG 688P: Programming for Biology (CBBG graduate core course)

Graduate Program Affiliations

  • BISI-Behavior, Ecology, Evolution, & Systematics (BEES)
  • BISI-Computational Biology, Bioinformatics, & Genomics (CBBG)
  • BISI-Molecular & Cellular Biology (MOCB)

Research Interests

Research in the Mount lab is devoted to understanding how multicellular organisms accomplish the correct processing of RNA from protein-coding genes. This involves identifying the elements of primary sequence information that determine where (and whether or not) splicing will occur, determining which components of the splicing machinery play especially salient roles in recognizing those signals, and determining how those factors act.

Recently, our focus has been increasingly directed towards the use of bioinformatics, primarily in collaborative projects. When the first eukaryotic genes were sequenced, and introns were discovered, similarity in the sequences at splice sites served as important clues to the way that splice sites were recognized. We have applied knowledge of how splice sites are recognized to the impact of human genetic variation on splicing, finding that a surprisingly large fraction of "Impact SNPs" may act through splicing.

Another current focus is on improving our ability to infer patterns of splicing, including unusual events (such as extremely small exons or splicing at sites that do not fit consensus) from available data (most often, short read RNAseq data). Ongoing research in this area is focused on comparison of existing methods for analysis of differential alternative splicing using RNA-seq data.


Education

B.A., Rice University, 1978
Ph.D., Yale University, 1983


All Publications

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Latest Publications via PubMed

Li M,Galimba K,Xiao Y,Dardick C,Mount SM,Callahan A,Liu Z
Plant J. 2022 Mar;109(6):1614-1629. doi: 10.1111/tpj.15633. Epub 2021 Dec 27
Zhang Y,Ren Q,Tang X,Liu S,Malzahn AA,Zhou J,Wang J,Yin D,Pan C,Yuan M,Huang L,Yang H,Zhao Y,Fang Q,Zheng X,Tian L,Cheng Y,Le Y,McCoy B,Franklin L,Selengut JD,Mount SM,Que Q,Zhang Y,Qi Y
Nat Commun. 2021 Mar 29;12(1):1944. doi: 10.1038/s41467-021-22330-w. Epub 2021 Mar 29
Sretenovic S,Yin D,Levav A,Selengut JD,Mount SM,Qi Y
Plant Commun. 2021 Mar 8;2(2):100101. doi: 10.1016/j.xplc.2020.100101. Epub 2020 Jul 22
Mount SM,Avsec Ž,Carmel L,Casadio R,Çelik MH,Chen K,Cheng J,Cohen NE,Fairbrother WG,Fenesh T,Gagneur J,Gotea V,Holzer T,Lin CF,Martelli PL,Naito T,Nguyen TYD,Savojardo C,Unger R,Wang R,Yang Y,Zhao H
Hum Mutat. 2019 Sep;40(9):1215-1224. doi: 10.1002/humu.23869. Epub 2019 Aug 19
Gunady MK,Mount SM,Corrada Bravo H
BMC Bioinformatics. 2019 Aug 13;20(1):421. doi: 10.1186/s12859-019-2947-6. Epub 2019 Aug 13
Shahan R,Zawora C,Wight H,Sittmann J,Wang W,Mount SM,Liu Z
Plant Physiol. 2018 Sep;178(1):202-216. doi: 10.1104/pp.18.00086. Epub 2018 Jul 10
Nazario-Toole AE,Robalino J,Okrah K,Corrada-Bravo H,Mount SM,Wu LP
J Immunol. 2018 Aug 15;201(4):1154-1164. doi: 10.4049/jimmunol.1800496. Epub 2018 Jul 11
Zhang XN,Shi Y,Powers JJ,Gowda NB,Zhang C,Ibrahim HMM,Ball HB,Chen SL,Lu H,Mount SM
BMC Genomics. 2017 Oct 11;18(1):772. doi: 10.1186/s12864-017-4183-7. Epub 2017 Oct 11
Buffalo V,Mount SM,Coop G
Genetics. 2016 Sep;204(1):57-75. doi: 10.1534/genetics.116.190041. Epub 2016 Jun 29