Dr. Juan Angueyra
Contact Info
Office: 301.405.1605
Lab: 301.405.3151
Juan Angueyra
Assistant Professor

Graduate Program Affiliations

• BISI-Molecular and Cellular Biology (MOCB)

• BISI-Physiological Systems (PSYS) 

• Neuroscience & Cognitive Science (NACS)


Research Interests

Because of its potential applications in regenerative medicine, one of the ultimate goals of neuroscience is to build a nervous system from scratch. Despite incredible advances over the last decades in identifying the different cell types and subtypes in each brain region ("parts list") and, in mapping the connectivity of the brain ("wiring diagram"), our ability to make functional organoids that contain many cell types is still in its infancy. The overarching goal of our group's research is to tackle two of the main hurdles in this field — the correct generation of parts and their appropriate wiring — by determining, during development, (1) how progenitor cells make decisions to acquire specific neural fates, (2) how these developing neurons make connections with specific postsynaptic partners and (3) which mechanisms are required to coordinate fate and connectivity locally and globally across an entire organ (patterning).

Our research focuses on the retina, because of its physical and experimental accessibility, and the near complete mapping of retinal cell subtypes and connectivity. It also exploits the technical advantages of zebrafish enabling both fast prototyping and deep mechanistical insights. Our ultimate goal is to use this developmental knowledge to establish methods and manipulations capable of directing cellular fate and of guiding rewiring, in the context of regenerative or replacement therapies in neurodegenerations or other conditions characterized by neuronal loss.


All Publications

 

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Latest Publications via PubMed

Kunze VP,Angueyra J,Ball JM,Thomsen MB,Li X,Sabnis A,Nadal-Nicolás FM,Li W
bioRxiv. 2023 Feb 14;:. pii: 2023.02.13.527055. doi: 10.1101/2023.02.13.527055. Epub 2023 Feb 14
Angueyra JM,Kunze VP,Patak LK,Kim H,Kindt K,Li W
Elife. 2023 Feb 6;12:. doi: 10.7554/eLife.81579. Epub 2023 Feb 6
Angueyra J,Li W
Cell Stem Cell. 2022 Mar 3;29(3):349-350. doi: 10.1016/j.stem.2022.02.005. Epub
Angueyra JM,Baudin J,Schwartz GW,Rieke F
J Neurosci. 2022 Feb 16;42(7):1254-1274. doi: 10.1523/JNEUROSCI.0793-21.2021. Epub 2021 Dec 23
Tilley DC,Angueyra JM,Eum KS,Kim H,Chao LH,Peng AW,Sack JT
J Gen Physiol. 2019 Mar 4;151(3):292-315. doi: 10.1085/jgp.201812213. Epub 2018 Nov 5
Baudin J,Angueyra JM,Sinha R,Rieke F
Elife. 2019 Jan 23;8:. doi: 10.7554/eLife.39166. Epub 2019 Jan 23
Angueyra JM,Kindt KS
Front Cell Dev Biol. 2018;6:110. doi: 10.3389/fcell.2018.00110. Epub 2018 Sep 19
Kiser PD,Zhang J,Sharma A,Angueyra JM,Kolesnikov AV,Badiee M,Tochtrop GP,Kinoshita J,Peachey NS,Li W,Kefalov VJ,Palczewski K
J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2
Wahlin KJ,Maruotti JA,Sripathi SR,Ball J,Angueyra JM,Kim C,Grebe R,Li W,Jones BW,Zack DJ
Sci Rep. 2017 Apr 10;7(1):766. doi: 10.1038/s41598-017-00774-9. Epub 2017 Apr 10