Profile photo of Carlos Machado
Contact Info
Phone: 301.405.9447
Fax: 301.314.9358
Office Address: 2121 Bioscience Research Bldg
Carlos Machado
Professor

Graduate Program Affiliations

  • BISI-Computational Biology, Bioinformatics, & Genomics (CBBG)
  • BISI-Behavior, Ecology, Evolution, & Systematics (BEES)

Research Interests

Work in our lab is centered on understanding the processes and mechanisms that have led to the evolution of new species and to the generation of genetic diversity in two study systems: species of the Drosophila pseudoobscura group, and the fig/fig-wasp mutualism. Common problems that we have been addressing in the two research systems are: What are the roles played by hybridization and introgression during the evolution of new species? What are the consequences of those processes on genetic variation at a genomic scale? Additional studies we are conducting with Drosophila are focused on using whole-genome expression arrays to identify genetic changes underlying phenotypic differences between closely related species, including genetic changes involved in regulatory hybrid dysfunction (gene expression changes affecting fertility or viability). Additional studies in the fig/fig-wasp mutualism are centered on understanding the causes and consequences of incongruent cophylogenetic patterns of divergence of closely related Neotropical figs and their pollinators, studying the geographical context of species diversification in the mutualism, and studying the population genetic consequences of evolution in subdivided populations. We use a combination of genomic, population genetic, and phylogenetic approaches to address all those questions. In addition to our main work on those two systems, we have returned to our previous work on the evolution of the human parasite Trypanosoma cruzi.


Education

Ph.D., University of California, Irvine, 1998. Evolutionary genetics and genomics, the process of species divergence, plant-insect coevolution.


All Publications

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Latest Publications via PubMed

Flores-López CA,Mitchell EA,Reisenman CE,Sarkar S,Williamson PC,Machado CA
Infect Genet Evol. 2022 Apr;99:105251. doi: 10.1016/j.meegid.2022.105251. Epub 2022 Feb 17
Satler JD,Herre EA,Heath TA,Machado CA,Zúñiga AG,Nason JD
Mol Ecol. 2022 Apr;31(7):2106-2123. doi: 10.1111/mec.16373. Epub 2022 Feb 7
Korunes KL,Machado CA,Noor MAF
Evolution. 2021 Jul;75(7):1820-1834. doi: 10.1111/evo.14278. Epub 2021 Jun 19
Wang R,Yang Y,Jing Y,Segar ST,Zhang Y,Wang G,Chen J,Liu QF,Chen S,Chen Y,Cruaud A,Ding YY,Dunn DW,Gao Q,Gilmartin PM,Jiang K,Kjellberg F,Li HQ,Li YY,Liu JQ,Liu M,Machado CA,Ming R,Rasplus JY,Tong X,Wen P,Yang HM,Yang JJ,Yin Y,Zhang XT,Zhang YY,Yu H,Yue Z,Compton SG,Chen XY
Nat Ecol Evol. 2021 Jul;5(7):974-986. doi: 10.1038/s41559-021-01469-1. Epub 2021 May 17
Wang G,Zhang X,Herre EA,McKey D,Machado CA,Yu WB,Cannon CH,Arnold ML,Pereira RAS,Ming R,Liu YF,Wang Y,Ma D,Chen J
Nat Commun. 2021 Feb 2;12(1):718. doi: 10.1038/s41467-021-20957-3. Epub 2021 Feb 2
Satler JD,Herre EA,Jandér KC,Eaton DAR,Machado CA,Heath TA,Nason JD
Evolution. 2019 Nov;73(11):2295-2311. doi: 10.1111/evo.13809. Epub 2019 Aug 8
Stein JC,Yu Y,Copetti D,Zwickl DJ,Zhang L,Zhang C,Chougule K,Gao D,Iwata A,Goicoechea JL,Wei S,Wang J,Liao Y,Wang M,Jacquemin J,Becker C,Kudrna D,Zhang J,Londono CEM,Song X,Lee S,Sanchez P,Zuccolo A,Ammiraju JSS,Talag J,Danowitz A,Rivera LF,Gschwend AR,Noutsos C,Wu CC,Kao SM,Zeng JW,Wei FJ,Zhao Q,Feng Q,El Baidouri M,Carpentier MC,Lasserre E,Cooke R,da Rosa Farias D,da Maia LC,Dos Santos RS,Nyberg KG,McNally KL,Mauleon R,Alexandrov N,Schmutz J,Flowers D,Fan C,Weigel D,Jena KK,Wicker T,Chen M,Han B,Henry R,Hsing YC,Kurata N,de Oliveira AC,Panaud O,Jackson SA,Machado CA,Sanderson MJ,Long M,Ware D,Wing RA
Nat Genet. 2018 Nov;50(11):1618. doi: 10.1038/s41588-018-0261-2. Epub
Krieger EM,Drager LF,Giorgi DMA,Pereira AC,Barreto-Filho JAS,Nogueira AR,Mill JG,Lotufo PA,Amodeo C,Batista MC,Bodanese LC,Carvalho ACC,Castro I,Chaves H,Costa EAS,Feitosa GS,Franco RJS,Fuchs FD,Guimarães AC,Jardim PC,Machado CA,Magalhães ME,Mion D Jr,Nascimento RM,Nobre F,Nóbrega AC,Ribeiro ALP,Rodrigues-Sobrinho CR,Sanjuliani AF,Teixeira MDCB,Krieger JE,ReHOT Investigators.
Hypertension. 2018 Apr;71(4):681-690. doi: 10.1161/HYPERTENSIONAHA.117.10662. Epub 2018 Feb 20
Stein JC,Yu Y,Copetti D,Zwickl DJ,Zhang L,Zhang C,Chougule K,Gao D,Iwata A,Goicoechea JL,Wei S,Wang J,Liao Y,Wang M,Jacquemin J,Becker C,Kudrna D,Zhang J,Londono CEM,Song X,Lee S,Sanchez P,Zuccolo A,Ammiraju JSS,Talag J,Danowitz A,Rivera LF,Gschwend AR,Noutsos C,Wu CC,Kao SM,Zeng JW,Wei FJ,Zhao Q,Feng Q,El Baidouri M,Carpentier MC,Lasserre E,Cooke R,Rosa Farias DD,da Maia LC,Dos Santos RS,Nyberg KG,McNally KL,Mauleon R,Alexandrov N,Schmutz J,Flowers D,Fan C,Weigel D,Jena KK,Wicker T,Chen M,Han B,Henry R,Hsing YC,Kurata N,de Oliveira AC,Panaud O,Jackson SA,Machado CA,Sanderson MJ,Long M,Ware D,Wing RA
Nat Genet. 2018 Feb;50(2):285-296. doi: 10.1038/s41588-018-0040-0. Epub 2018 Jan 22
Morales Salinas A,Coca A,Olsen MH,Sanchez RA,Sebba-Barroso WK,Kones R,Bertomeu-Martinez V,Sobrino J,Alcocer L,Pineiro DJ,Lanas F,Machado CA,Aguirre-Palacios F,Ortellado J,Perez G,Sabio R,Landrove O,Rodriguez-Leyva D,Duenas-Herrera A,Rodriguez Portelles A,Parra-Carrillo JZ,Piskorz DL,Bryce-Moncloa A,Waisman G,Yano Y,Ventura H,Orias M,Prabhakaran D,Sundström J,Wang J,Burrell LM,Schutte AE,Lopez-Jaramillo P,Barbosa E,Redon J,Weber MA,Lavie CJ,Ramirez A,Ordunez P,Yusuf S,Zanchetti A
Curr Probl Cardiol. 2017 Jul;42(7):198-225. doi: 10.1016/j.cpcardiol.2017.03.001. Epub 2017 Mar 8
López-Olmos K,Markow TA,Machado CA
J Mol Evol. 2017 Jun;84(5-6):285-294. doi: 10.1007/s00239-017-9798-4. Epub 2017 Jun 28
Sanchez-Flores A,Peñaloza F,Carpinteyro-Ponce J,Nazario-Yepiz N,Abreu-Goodger C,Machado CA,Markow TA
G3 (Bethesda). 2016 Oct 13;6(10):3097-3105. doi: 10.1534/g3.116.033779. Epub 2016 Oct 13
Nyberg KG,Machado CA
Genome Biol Evol. 2016 Jun 27;8(6):1839-58. doi: 10.1093/gbe/evw116. Epub 2016 Jun 27
Veiga EV,Daniel AC,Bortolloto LA,Machado CA,Plavinik FL,CláudiaIrigoyen M,Campbell N,Kenerson J,Cloutier L
J Clin Hypertens (Greenwich). 2016 Jan;18(1):7-9. doi: 10.1111/jch.12676. Epub 2015 Oct 12
Tian E,Nason JD,Machado CA,Zheng L,Yu H,Kjellberg F
Mol Ecol. 2015 Dec;24(23):5976-91. doi: 10.1111/mec.13438. Epub 2015 Nov 25
Martinson EO,Hackett JD,Machado CA,Arnold AE
PLoS One. 2015;10(6):e0130745. doi: 10.1371/journal.pone.0130745. Epub 2015 Jun 19