Patrick Kanold
Professor
Contact
Email: pkanold@umd.edu
Office Phone: 301.405.5741
Lab: 301.405.3145
Fax: 301.314.9358
Office Address: 1116 Bioscience Research Building
URL:
http://clfs.umd.edu/biology/faculty/kanold/Home.html
http://kanold.org
Graduate Program Affiliations
Research Interests
Dr. Kanold studies the development and plasticity of the brain, in particular how periods of learning and plasticity are initiated and controlled. His work focuses on the development of the central auditory and visual system in particular on the role of early cortical circuits in brain wiring. He uses advanced neurophysiological, in vivo imaging, optogenetic, molecular and computational techniques. His work furthers our understanding of how prenatal and postnatal brain injury contribute to neurodevelopmental disorders such as cerebral palsy, epilepsy and schizophrenia.
Recent Publications
P.O. Kanold, P. Kara, C. Reid, C. J. Shatz, “Subplate neurons are required for functional maturation of cortical columns”,Science 301(5632): 521-5, 2003
Y. Tagawa*, P.O. Kanold*, M. Majdan, C. J. Shatz "Multiple periods of functional ocular dominance plasticity in mouse visual cortex", Nature Neuroscience 8(3): 380-8, 2005
Syken J, Grandpre T, Kanold PO, Shatz CJ. PirB restricts ocular-dominance plasticity in visual cortex. Science313(5794):1795-800. 2006
Kanold PO, Shatz CJ. Subplate neurons regulate maturation of cortical inhibition and outcome of ocular dominance plasticity. Neuron 51(5):627-38. 2006
Butts DA, Kanold PO, Shatz CJ. A burst-based Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. PLoS Biol. 5(3):e61. 2007;
P.O. Kanold, Y.A. Kim, T. GrandPre, C. J. Shatz, "Co-regulation of ocular dominance plasticity and NMDA receptor subunit expression in glutamic acid decarboxylase-65 knock-out mice”, J. Physiology (London), 587(Pt 12):2857-67. 2009
P.O. Kanold, “Subplate neurons: crucial regulators of cortical development and plasticity”, Frontiers in Neuroanatomy, 3:16. 2009
A. Datwani, M.J. McConnell, P.O. Kanold, K.D. Micheva, B. Busse, M. Shamloo, S.J. Smith, and C.J. Shatz,, “Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity”, Neuron, 64: 463–470, 2009
Zhao, JPY Kao, P.O. Kanold,"Functional microcircuits in neonatal cortex connect thalamus and layer 4", Journal of Neuroscience, 29(49):15479-88, 2009.
S. Bandyopadhyay, S. Shamma, P.O. Kanold,"Dichotomy of functional organization in the mouse auditory cortex", Nature Neuroscience, 2010.
P.O. Kanold, H.J. Luhmann “The subplate and early cortical circuits”, Annual Review Neuroscience, 33:23-48 2010
D.A. Butts, P.O. Kanold, “The role of STDP in development”, Frontiers in Synaptic Neurosciences, 2:30. doi:10.3389. 2010
P.O. Kanold, K. A. Davis, E.D. Young, “Somatosensory context alters auditory responses in the cochlear nucleus”, J. Neurophysiology, 105(3): 1063-70, 2011
F. Postma, CH Liu. C Dietsche. M. Khan, H-K. Lee, D. Paul, P.O. Kanold, “Electrical synapses formed by Connexin36 regulate inhibition and experience-dependent plasticity”, Proceedings of the National Academy of Sciences, 108(33):13770-5, 2011
E. Tolner*, A Sheikh*. A Yukin.K. Kaila, P.O. Kanold, “Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex”, Journal of Neuroscience, 32(2): 692-702, 2012
Viswanathan S., Bandyopadhyay S. , Kao J.P.Y., Kanold P.O. “Changing microcircuits in the subplate of the developing cortex”, Journal of Neuroscience, 32(5): 1589-601, 2012
Winkowski D., Kanold P.O. “Laminar transformation of frequency organization in auditory cortex”, Journal of Neuroscience, 33(4): 1498-508, 2013
Winkowski D.*, Bandyopadhyay S.*, Shamma S., Kanold P.O. “Frontal cortex activation causes rapid plasticity of auditory cortical processing”, Journal of Neuroscience, 33(46): 18134-48, 2013
Awards
2007 Ralph E Powe Award
2010 Alfred P. Sloan Foundation
2013 NOHR/ARo Burt Evans Award
Education
Dipl. Ing (M.Sc.), Technische Universität Berlin, Germany, 1994
Ph.D., Johns Hopkins University, 2000
PostDoc, Harvard Medical School 2000-2005
Instructor, Harvard Medical School 2005-2006
Contact
Email: pkanold@umd.edu
Office Phone: 301.405.5741
Lab: 301.405.3145
Fax: 301.314.9358
Office Address: 1116 Bioscience Research Building
URL:
http://clfs.umd.edu/biology/faculty/kanold/Home.html
http://kanold.org
Graduate Program Affiliations
- Neuroscience & Cognitive Science (NACS)
- BISI - BISI-Physiological Systems (PSYS)
- Biophysics
Research Interests
Dr. Kanold studies the development and plasticity of the brain, in particular how periods of learning and plasticity are initiated and controlled. His work focuses on the development of the central auditory and visual system in particular on the role of early cortical circuits in brain wiring. He uses advanced neurophysiological, in vivo imaging, optogenetic, molecular and computational techniques. His work furthers our understanding of how prenatal and postnatal brain injury contribute to neurodevelopmental disorders such as cerebral palsy, epilepsy and schizophrenia.
Recent Publications
P.O. Kanold, P. Kara, C. Reid, C. J. Shatz, “Subplate neurons are required for functional maturation of cortical columns”,Science 301(5632): 521-5, 2003
Y. Tagawa*, P.O. Kanold*, M. Majdan, C. J. Shatz "Multiple periods of functional ocular dominance plasticity in mouse visual cortex", Nature Neuroscience 8(3): 380-8, 2005
Syken J, Grandpre T, Kanold PO, Shatz CJ. PirB restricts ocular-dominance plasticity in visual cortex. Science313(5794):1795-800. 2006
Kanold PO, Shatz CJ. Subplate neurons regulate maturation of cortical inhibition and outcome of ocular dominance plasticity. Neuron 51(5):627-38. 2006
Butts DA, Kanold PO, Shatz CJ. A burst-based Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. PLoS Biol. 5(3):e61. 2007;
P.O. Kanold, Y.A. Kim, T. GrandPre, C. J. Shatz, "Co-regulation of ocular dominance plasticity and NMDA receptor subunit expression in glutamic acid decarboxylase-65 knock-out mice”, J. Physiology (London), 587(Pt 12):2857-67. 2009
P.O. Kanold, “Subplate neurons: crucial regulators of cortical development and plasticity”, Frontiers in Neuroanatomy, 3:16. 2009
A. Datwani, M.J. McConnell, P.O. Kanold, K.D. Micheva, B. Busse, M. Shamloo, S.J. Smith, and C.J. Shatz,, “Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity”, Neuron, 64: 463–470, 2009
Zhao, JPY Kao, P.O. Kanold,"Functional microcircuits in neonatal cortex connect thalamus and layer 4", Journal of Neuroscience, 29(49):15479-88, 2009.
S. Bandyopadhyay, S. Shamma, P.O. Kanold,"Dichotomy of functional organization in the mouse auditory cortex", Nature Neuroscience, 2010.
P.O. Kanold, H.J. Luhmann “The subplate and early cortical circuits”, Annual Review Neuroscience, 33:23-48 2010
D.A. Butts, P.O. Kanold, “The role of STDP in development”, Frontiers in Synaptic Neurosciences, 2:30. doi:10.3389. 2010
P.O. Kanold, K. A. Davis, E.D. Young, “Somatosensory context alters auditory responses in the cochlear nucleus”, J. Neurophysiology, 105(3): 1063-70, 2011
F. Postma, CH Liu. C Dietsche. M. Khan, H-K. Lee, D. Paul, P.O. Kanold, “Electrical synapses formed by Connexin36 regulate inhibition and experience-dependent plasticity”, Proceedings of the National Academy of Sciences, 108(33):13770-5, 2011
E. Tolner*, A Sheikh*. A Yukin.K. Kaila, P.O. Kanold, “Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex”, Journal of Neuroscience, 32(2): 692-702, 2012
Viswanathan S., Bandyopadhyay S. , Kao J.P.Y., Kanold P.O. “Changing microcircuits in the subplate of the developing cortex”, Journal of Neuroscience, 32(5): 1589-601, 2012
Winkowski D., Kanold P.O. “Laminar transformation of frequency organization in auditory cortex”, Journal of Neuroscience, 33(4): 1498-508, 2013
Winkowski D.*, Bandyopadhyay S.*, Shamma S., Kanold P.O. “Frontal cortex activation causes rapid plasticity of auditory cortical processing”, Journal of Neuroscience, 33(46): 18134-48, 2013
Awards
2007 Ralph E Powe Award
2010 Alfred P. Sloan Foundation
2013 NOHR/ARo Burt Evans Award
Education
Dipl. Ing (M.Sc.), Technische Universität Berlin, Germany, 1994
Ph.D., Johns Hopkins University, 2000
PostDoc, Harvard Medical School 2000-2005
Instructor, Harvard Medical School 2005-2006